National Certified Addiction Counselor, Level I (NCAC I) Practice Exam

Which of the following is an effect of amphetamines on metabolism in the synaptic cleft?

1. Stimulates catecholamine reuptake

2. Enhances metabolism of serotonin

3. Blocks catecholamine reuptake

4. Inhibits dopamine production

The correct answer is: Blocks catecholamine reuptake

Amphetamines primarily act as stimulants by increasing the levels of certain neurotransmitters in the brain, particularly catecholamines like dopamine and norepinephrine. The correct option highlights that amphetamines block the reuptake of catecholamines in the synaptic cleft, which leads to an increase in their availability and effects. This mechanism is a significant factor in how amphetamines produce their stimulating effects, as the blockade of reuptake ensures that neurotransmitters remain active in the synapse for a longer period. In contrast, the other options do not accurately describe the action of amphetamines. Stimulating catecholamine reuptake would reduce their levels in the synapse, which is contrary to the action of amphetamines. Enhancing the metabolism of serotonin does not relate to how amphetamines primarily function, as their main influence is on catecholamines rather than serotonin directly. Lastly, inhibiting dopamine production goes against the stimulant effects of amphetamines, which actually encourage increased dopamine release and availability rather than inhibiting its production.