National Certified Addiction Counselor, Level I (NCAC I) Practice Exam

What mechanism does THC utilize to produce its psychoactive effects?

1. It stimulates opioid receptors in the brain

2. It binds to cannabinoid receptors meant for anandamide and 2-AG

3. It inhibits serotonin reuptake

4. It enhances dopamine release in the brain

The correct answer is: It binds to cannabinoid receptors meant for anandamide and 2-AG

The mechanism by which THC (tetrahydrocannabinol) produces its psychoactive effects is through its binding to cannabinoid receptors in the brain, specifically the CB1 receptors. These receptors are part of the endocannabinoid system, which also includes naturally occurring compounds like anandamide and 2-arachidonoylglycerol (2-AG). When THC binds to the CB1 receptors, it mimics the effects of these endocannabinoids, leading to the various psychoactive effects typically associated with cannabis use. Cannabinoid receptors play a crucial role in modulating neurotransmitter release in numerous brain regions, influencing mood, memory, pain sensation, and other cognitive functions. The activation of these receptors can lead to increased pleasure, altered perception of time, and changes in coordination, contributing to the overall experience of being "high." The other options do not accurately represent the primary action of THC. For instance, opioid receptors are associated with the effects of opioids, while serotonin reuptake inhibition is more related to certain antidepressants. Additionally, while THC can influence dopamine release, especially in areas of the brain associated with reward, this is secondary to its primary mechanism of action through cannabinoid receptors. Thus, binding to cannabinoid receptors