National Certified Addiction Counselor, Level I (NCAC I) Practice Exam 2026 – Comprehensive All-in-One Guide to Exam Success!

Withdrawal from barbiturates poses a significant risk of seizures and potentially death due to the physiological dependence that can develop with prolonged use. Barbiturates are central nervous system depressants, and when an individual who has been using them regularly suddenly stops, their body can react severely. The brain has adapted to the presence of the drug, and its sudden absence can lead to hyperactivity in the nervous system.

The risk of seizures is particularly heightened because, during withdrawal, there is an imbalance between excitatory and inhibitory neurotransmission. This imbalance increases the likelihood of seizure activity. In severe cases, these seizures can lead to status epilepticus, a life-threatening condition. Moreover, the risk of complications and mortality increases with the intensity of withdrawal symptoms, which can include severe agitation, hallucinations, and delirium.

Other possible concerns during withdrawal might include psychological issues or physical health complications, but the direct and life-threatening risks associated with seizures make withdrawal from barbiturates particularly dangerous.