National Certified Addiction Counselor, Level I (NCAC I) Practice Exam 2026 – Comprehensive All-in-One Guide to Exam Success!

Major depression is commonly associated with MDMA use due to the drug’s impact on serotonin levels in the brain. MDMA, also known as ecstasy, causes a significant release of serotonin when it is used. After the effects wear off, there can be a substantial depletion of serotonin, leading to feelings of sadness, lethargy, and mood disturbances. Users may experience a crash that can including major depression, anxiety, and irritability as their brain chemistry tries to rebalance after the heightened stimulation caused by the drug.

This withdrawal symptom is particularly concerning because it can affect a person's mental health significantly and may result in prolonged episodes of depression. Understanding this aspect of MDMA use is vital for addiction counselors when addressing the needs of individuals who may be struggling with the psychological effects of the drug as part of their recovery process.